Epub 2008 Jul 14. For some people, bone deteriorates at such a fast pace that they develop osteoporosis, a condition where your bones become fragile and are more likely to fracture. The slightest, most unexpected movement or event might trigger a fracture or broken bone in a woman recovering from an eating disorder who has osteoporosis. Also is important for them to take enough calcium and vitamin D, because these suplements avert rapid bone loss. "It seems that high blood sugar may shut down bone formation, just as with steroids," says Beatrice Edwards, MD, MPH, associate professor of medicine and director of the Bone Health and Osteoporosis Center at Northwestern University Feinberg School of Medicine. Endocr Rev. Dentures/Bridgework: Unanchored dentures are placed on top of the gum line, and therefore do not provide any direct stimulation to the underlying alveolar bone. An endocrine hormone used in clinical trials as an anti-obesity and anti-diabetes drug causes significant and rapid bone loss in mice, raising concerns about … However, there are a number of medical conditions and medications that can cause more rapid bone loss — the most common conditions are hyperparathyroidism, hyperthyroidism, vitamin D deficiency and celiac disease, and the most common medications are steroids and aromatase inhibitors. She is the author of "The Everything Health Guide to Arthritis." These disorders are poorly recognized, resulting mainly from systemic diseases, frailty, immobilization, and immunosuppressive drugs, such as glucocorticoids and the calcineurin inhibitors. "Anything that impedes the growth of bone during these years puts you at greater risk for osteoporosis," says Edwards. Even in the absence of glucocorticoids, CIs can cause pro-found bone loss. People with both lupus and RA usually take corticosteroids for an extended period of time to manage their symptoms. Epub 2008 Jul 14. the initial phase, the rapid bone loss may be in part caused by increased osteoclastic activity, the mechanism of which is unclear, although pathophysiological factors … Hyperthyroidism occurs when the thyroid gland -- a small, butterfly-shaped gland at the base of the neck -- becomes overactive and produces too much thyroid hormone. In controls, bone loss was 9.5% in the lumbar spine and 4.6% in the femoral neck, while in the clodronate group, bone loss was 5.9% and 0.4%, respectively, at 2 years. Lupus is a particular problem because it is common in women between the ages of 15 and 45 -- often during the peak bone-building years up to age 30. Rapid, unexplained weight loss may an indication of cancer. The main causes of bone loss include: Periodontitis. In the case of knees and hips, replacement surgery is the solution. You probably know some of the leading risk factors for osteoporosis -- being female and past menopause, smoking, or having a small frame. Without a clinical exam and radiographs it is very difficult to know the exact cause of the rapid bone loss. CONCLUSION: Chemotherapy-induced ovarian failure causes rapid bone loss in premenopausal breast cancer patients. Arthritis Rheum. Consult a physician immediately for evaluation of the causes. Causes of bone loss around teeth . 37 years experience Internal Medicine. In severe underweight or rapid weight loss, the cellular bone marrow is replaced by a dysfunctional “goo” that does not produce cells normally. Reduced bone mass and increased fracture risk are complications of idiopathic human inflammatory bowel disease (IBD) , , .The etiology of bone loss in IBD is multi-factorial and includes vitamin D and calcium deficiencies, glucocorticoid therapy, decreased gonadal function, and deleterious effects of circulating cytokines derived from the inflamed intestine on bone metabolism. Over time, this can lead to weak brittle bones with an increased risk of fracture, a condition known as osteoporosis. A series of studies found that steroid drugs, known for inducing bone loss with prolonged use, actually help suppress a molecule that’s key to the rapid bone loss process. Epub 2020 Jun 8. Inadequate nutrients. People with rapid bone loss are in risk because it takes only a little pressure to cause a fracture. Also known as gum disease, periodontitis is one of the most common causes of bone loss around the teeth. The good news is; it is possible! Ideally, patients need to be identified early and preventative therapy initiated promptly to avoid the rapid bone loss and fractures. In controls, bone loss was 9.5% in the lumbar spine and 4.6% in the femoral neck, while in the clodronate group, bone loss was 5.9% and 0.4%, respectively, at 2 years. For example: 1. 2018 Oct 1;39(5):701-718. doi: 10.1210/er.2018-00050. Originally, the deleterious effect of CsA was demon-strated in rats where severe and rapid bone loss occurred with a metabolic profile that revealed increased osteocalcin and 1,25-dihydroxyvitamin D synthesis. Med Pediatr Oncol. Men lost more weight, and more fat mass than lean mass, compared to the women, LeBoff said. Dentures/Bridgework: Unanchored dentures are placed on top of the gum line, and therefore do not provide any direct stimulation to the underlying alveolar bone. 2007 Jan;18(1):223-34. doi: 10.1681/ASN.2006050427. The most common cause of hair loss is hereditary male- or female-pattern baldness. A systematic review and meta-analysis of bone loss in space travelers. American College of Rheumatology Ad Hoc Committee on Glucocorticoid-Induced Osteoporosis.